Drug interactions
Rasagiline + Trazodone
Severity: Contraindicated
Rasagiline and Trazodone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining trazodone with a monoamine oxidase inhibitor such as rasagiline can precipitate serotonin syndrome, with agitation, hyperthermia, myoclonus and autonomic instability. Labeling for both drugs warns against concurrent use.
What this interaction means in plain words
Rasagiline and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rasagiline belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic effect from serotonin reuptake inhibition by trazodone and reduced serotonin breakdown through MAO inhibition.
What to do
Do not coadminister. Allow 14 days after stopping rasagiline before starting trazodone and at least 14 days after stopping trazodone before starting rasagiline.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Trazodone?
MediHelp rates the interaction as contraindicated. Rasagiline and Trazodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining trazodone with a monoamine oxidase inhibitor such as rasagiline can precipitate serotonin syndrome, with agitation, hyperthermia, myoclonus and autonomic instability. Labeling for both drugs warns against concurrent use.
How serious is the interaction between Rasagiline and Trazodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow 14 days after stopping rasagiline before starting trazodone and at least 14 days after stopping trazodone before starting rasagiline.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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