Drug interactions
Rasagiline + Zileuton
Severity: Moderate
Rasagiline and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is cleared mainly by CYP1A2, so inhibitors such as zileuton may raise its exposure. Higher levels can increase the risk of dopaminergic and MAO-related adverse effects.
What this interaction means in plain words
Rasagiline and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rasagiline belongs to Central Nervous System; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, reducing rasagiline clearance.
What to do
Limit rasagiline to 0.5 mg daily during use of CYP1A2 inhibitors. Monitor for adverse effects such as hypotension and dyskinesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Rasagiline with Zileuton?
MediHelp rates the interaction as moderate. Rasagiline and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is cleared mainly by CYP1A2, so inhibitors such as zileuton may raise its exposure. Higher levels can increase the risk of dopaminergic and MAO-related adverse effects.
How serious is the interaction between Rasagiline and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rasagiline to 0.5 mg daily during use of CYP1A2 inhibitors. Monitor for adverse effects such as hypotension and dyskinesia.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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