Drug interactions
Regorafenib + Ribociclib
Severity: Moderate
Regorafenib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and may raise regorafenib concentrations, although regorafenib active metabolite formation is also affected. Increased exposure could worsen hepatotoxicity, hypertension and hand-foot skin reaction.
What this interaction means in plain words
Regorafenib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolism of regorafenib.
What to do
Monitor liver function tests, blood pressure and skin toxicity closely. Reduce or interrupt regorafenib if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Regorafenib with Ribociclib?
MediHelp rates the interaction as moderate. Regorafenib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and may raise regorafenib concentrations, although regorafenib active metabolite formation is also affected. Increased exposure could worsen hepatotoxicity, hypertension and hand-foot skin reaction.
How serious is the interaction between Regorafenib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests, blood pressure and skin toxicity closely. Reduce or interrupt regorafenib if adverse effects emerge.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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