Drug interactions
Regorafenib + Rosuvastatin
Severity: Moderate
Regorafenib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib can inhibit the efflux transporter BCRP, which limits intestinal absorption of rosuvastatin. Systemic rosuvastatin exposure may rise, increasing the chance of muscle toxicity such as myalgia or myopathy.
What this interaction means in plain words
Regorafenib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Regorafenib inhibits BCRP (ABCG2), reducing efflux of rosuvastatin and raising its systemic exposure.
What to do
Monitor for muscle pain, weakness and CK elevation during combined therapy. Consider using a lower rosuvastatin dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Rosuvastatin?
MediHelp rates the interaction as moderate. Regorafenib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib can inhibit the efflux transporter BCRP, which limits intestinal absorption of rosuvastatin. Systemic rosuvastatin exposure may rise, increasing the chance of muscle toxicity such as myalgia or myopathy.
How serious is the interaction between Regorafenib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation during combined therapy. Consider using a lower rosuvastatin dose if symptoms develop.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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