Drug interactions
Regorafenib + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Regorafenib and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib inhibits BCRP, and the components sofosbuvir, velpatasvir and voxilaprevir are BCRP substrates or inhibitors. Intestinal absorption of these antivirals may increase, though the clinical effect is probably small.
What this interaction means in plain words
Regorafenib and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Regorafenib inhibits BCRP (ABCG2) efflux, which may increase systemic exposure to the antiviral components.
What to do
Monitor for adverse effects of the antiviral regimen such as headache, fatigue and gastrointestinal upset, and for regorafenib hepatotoxicity with liver tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Regorafenib
Frequently asked questions
Can I take Regorafenib with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Regorafenib and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib inhibits BCRP, and the components sofosbuvir, velpatasvir and voxilaprevir are BCRP substrates or inhibitors. Intestinal absorption of these antivirals may increase, though the clinical effect is probably small.
How serious is the interaction between Regorafenib and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the antiviral regimen such as headache, fatigue and gastrointestinal upset, and for regorafenib hepatotoxicity with liver tests.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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