Drug interactions
Regorafenib + Tazemetostat
Severity: Moderate
Regorafenib and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A inducer and may lower regorafenib exposure. This could reduce regorafenib efficacy.
What this interaction means in plain words
Regorafenib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat induces CYP3A4, increasing regorafenib metabolism.
What to do
Monitor for reduced clinical response to regorafenib and consider alternatives if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Tazemetostat
Frequently asked questions
Can I take Regorafenib with Tazemetostat?
MediHelp rates the interaction as moderate. Regorafenib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A inducer and may lower regorafenib exposure. This could reduce regorafenib efficacy.
How serious is the interaction between Regorafenib and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clinical response to regorafenib and consider alternatives if efficacy is lost.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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