Drug interactions
Repaglinide + Rosuvastatin
Severity: Minor
Repaglinide and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is an OATP1B1 substrate and weak inhibitor in vitro, so it could in theory compete with rosuvastatin for hepatic uptake. No clinically significant interaction is established.
What this interaction means in plain words
Repaglinide and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Repaglinide belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
Why it happens
Possible competition at hepatic OATP1B1 uptake; clinical relevance is unproven.
What to do
No dose adjustment is needed. Counsel the patient to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Rosuvastatin?
MediHelp rates the interaction as minor. Repaglinide and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Repaglinide is an OATP1B1 substrate and weak inhibitor in vitro, so it could in theory compete with rosuvastatin for hepatic uptake. No clinically significant interaction is established.
How serious is the interaction between Repaglinide and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Counsel the patient to report muscle pain or weakness.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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