Drug interactions
Repaglinide + Talquetamab
Severity: Moderate
Repaglinide and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talquetamab causes cytokine release, which can transiently suppress CYP enzyme activity. This may raise exposure to CYP substrates like repaglinide and increase hypoglycemia risk.
What this interaction means in plain words
Repaglinide and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Talquetamab belongs to Oncology.
Why it happens
Cytokine release suppresses CYP3A4 and CYP2C8 expression, decreasing repaglinide clearance.
What to do
Monitor blood glucose closely during step-up dosing and for about two weeks after the first treatment dose, and during any cytokine release syndrome. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Repaglinide with Talquetamab?
MediHelp rates the interaction as moderate. Repaglinide and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talquetamab causes cytokine release, which can transiently suppress CYP enzyme activity. This may raise exposure to CYP substrates like repaglinide and increase hypoglycemia risk.
How serious is the interaction between Repaglinide and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during step-up dosing and for about two weeks after the first treatment dose, and during any cytokine release syndrome. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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