Drug interactions
Repaglinide + Tecovirimat
Severity: Moderate
Repaglinide and Tecovirimat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and weakly induces CYP3A4, so repaglinide levels may shift in either direction. The net effect is usually small, but hypoglycemia is possible.
What this interaction means in plain words
Repaglinide and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP2C8 (a repaglinide pathway) with weak CYP3A4 induction produces variable changes in repaglinide clearance.
What to do
Monitor blood glucose during and after the tecovirimat course. Adjust the repaglinide dose if hypoglycemia or hyperglycemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Repaglinide and Tecovirimat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Repaglinide with Tecovirimat?
MediHelp rates the interaction as moderate. Repaglinide and Tecovirimat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and weakly induces CYP3A4, so repaglinide levels may shift in either direction. The net effect is usually small, but hypoglycemia is possible.
How serious is the interaction between Repaglinide and Tecovirimat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after the tecovirimat course. Adjust the repaglinide dose if hypoglycemia or hyperglycemia appears.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
