Drug interactions
Repaglinide + Testosterone
Severity: Minor
Repaglinide and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone may improve insulin sensitivity and lower blood glucose, potentially enhancing the effect of repaglinide. Hypoglycemia is possible in patients with diabetes.
What this interaction means in plain words
Repaglinide and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Repaglinide belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Additive glucose lowering through androgen-related improvement in insulin sensitivity.
What to do
Monitor blood glucose when testosterone is started or adjusted. Reduce the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Repaglinide with Testosterone?
MediHelp rates the interaction as minor. Repaglinide and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone may improve insulin sensitivity and lower blood glucose, potentially enhancing the effect of repaglinide. Hypoglycemia is possible in patients with diabetes.
How serious is the interaction between Repaglinide and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when testosterone is started or adjusted. Reduce the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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