Drug interactions
Repaglinide + Voriconazole
Severity: Moderate
Repaglinide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, and repaglinide is cleared by CYP3A4 and CYP2C8, so repaglinide exposure may increase. This can lead to prolonged or excessive glucose lowering and hypoglycemia.
What this interaction means in plain words
Repaglinide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Repaglinide belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by voriconazole decreases repaglinide metabolism.
What to do
Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs. Counsel patients on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Repaglinide with Voriconazole?
MediHelp rates the interaction as moderate. Repaglinide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4, and repaglinide is cleared by CYP3A4 and CYP2C8, so repaglinide exposure may increase. This can lead to prolonged or excessive glucose lowering and hypoglycemia.
How serious is the interaction between Repaglinide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the repaglinide dose if hypoglycemia occurs. Counsel patients on recognizing hypoglycemia.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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