Drug interactions
Revefenacin + Umeclidinium-vilanterol
Severity: Moderate
Revefenacin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both umeclidinium and revefenacin are long-acting inhaled muscarinic antagonists, so combining them duplicates therapy. This raises the risk of anticholinergic effects such as dry mouth, urinary retention and glaucoma worsening without added benefit.
What this interaction means in plain words
Revefenacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Revefenacin belongs to Respiratory; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Therapeutic duplication with additive antimuscarinic effects.
What to do
Do not use two long-acting muscarinic antagonists together; select a single agent. If both have been used, stop one and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Revefenacin
- Cyclosporin + Revefenacin Major
- Indacaterol-glycopyrronium + Revefenacin Major
- Revefenacin + Rifampicin Major
- Revefenacin + Tiotropium Major
- Atropine + Revefenacin Moderate
- Benztropine + Revefenacin Moderate
Frequently asked questions
Can I take Revefenacin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Revefenacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both umeclidinium and revefenacin are long-acting inhaled muscarinic antagonists, so combining them duplicates therapy. This raises the risk of anticholinergic effects such as dry mouth, urinary retention and glaucoma worsening without added benefit.
How serious is the interaction between Revefenacin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use two long-acting muscarinic antagonists together; select a single agent. If both have been used, stop one and monitor for anticholinergic effects.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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