Drug interactions
Ribociclib + Rifapentine
Severity: Major
Ribociclib and Rifapentine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can substantially lower ribociclib plasma concentrations, which may reduce antitumor efficacy. The effect is expected to be similar to that of other strong inducers such as rifampin, although rifapentine is somewhat less potent.
What this interaction means in plain words
Ribociclib and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4, accelerating ribociclib metabolism.
What to do
Avoid the combination where possible and use an alternative antimycobacterial regimen; labeling advises avoiding strong CYP3A4 inducers with ribociclib.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Ribociclib with Rifapentine?
MediHelp rates the interaction as major. Ribociclib and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces CYP3A4 and can substantially lower ribociclib plasma concentrations, which may reduce antitumor efficacy. The effect is expected to be similar to that of other strong inducers such as rifampin, although rifapentine is somewhat less potent.
How serious is the interaction between Ribociclib and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antimycobacterial regimen; labeling advises avoiding strong CYP3A4 inducers with ribociclib.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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