Drug interactions
Ribociclib + Riociguat
Severity: Minor
Ribociclib and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 at clinical doses and could modestly raise riociguat exposure. Riociguat is cleared by several CYP enzymes, so the effect is likely small, though higher levels could add to hypotension.
What this interaction means in plain words
Ribociclib and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Riociguat belongs to Cardiovascular.
Why it happens
Ribociclib inhibits CYP3A4, which is one of several pathways involved in riociguat metabolism.
What to do
No routine dose change is needed; monitor blood pressure and symptoms of hypotension when starting or stopping ribociclib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Ribociclib with Riociguat?
MediHelp rates the interaction as minor. Ribociclib and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib inhibits CYP3A4 at clinical doses and could modestly raise riociguat exposure. Riociguat is cleared by several CYP enzymes, so the effect is likely small, though higher levels could add to hypotension.
How serious is the interaction between Ribociclib and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood pressure and symptoms of hypotension when starting or stopping ribociclib.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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