Drug interactions
Ribociclib + Saxagliptin-metformin
Severity: Moderate
Ribociclib and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and may increase saxagliptin exposure. It may also raise metformin exposure through transporter inhibition. Increased adverse effects of either drug are possible.
What this interaction means in plain words
Ribociclib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of saxagliptin, with possible inhibition of renal transporters (MATE1/OCT2) affecting metformin.
What to do
Monitor glucose and for adverse effects. Consider limiting saxagliptin to 2.5 mg daily during ribociclib therapy where the combination product allows.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Ribociclib and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a CYP3A4 inhibitor and may increase saxagliptin exposure. It may also raise metformin exposure through transporter inhibition. Increased adverse effects of either drug are possible.
How serious is the interaction between Ribociclib and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and for adverse effects. Consider limiting saxagliptin to 2.5 mg daily during ribociclib therapy where the combination product allows.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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