Drug interactions
Ribociclib + Sparsentan
Severity: Moderate
Ribociclib and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a CYP3A4 substrate and ribociclib, a moderate CYP3A4 inhibitor, may increase its exposure. This could heighten dose-related adverse effects such as hypotension, hyperkalemia, edema and reduced kidney function.
What this interaction means in plain words
Ribociclib and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Sparsentan belongs to Genitourinary.
Why it happens
Ribociclib inhibits CYP3A4, decreasing sparsentan metabolism.
What to do
No empirical dose change is required, but monitor blood pressure, serum potassium, edema and renal function regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ribociclib with Sparsentan?
MediHelp rates the interaction as moderate. Ribociclib and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan is a CYP3A4 substrate and ribociclib, a moderate CYP3A4 inhibitor, may increase its exposure. This could heighten dose-related adverse effects such as hypotension, hyperkalemia, edema and reduced kidney function.
How serious is the interaction between Ribociclib and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is required, but monitor blood pressure, serum potassium, edema and renal function regularly.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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