Drug interactions
Ribociclib + Sufentanil
Severity: Moderate
Ribociclib and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared mainly by CYP3A4, so ribociclib may raise its levels and prolong opioid effects. This increases the risk of respiratory depression and excessive sedation.
What this interaction means in plain words
Ribociclib and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Sufentanil belongs to Musculoskeletal.
Why it happens
Ribociclib inhibits CYP3A4, reducing sufentanil clearance.
What to do
Monitor respiratory rate and sedation and titrate sufentanil to the lowest effective dose; extend observation after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Ribociclib with Sufentanil?
MediHelp rates the interaction as moderate. Ribociclib and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is cleared mainly by CYP3A4, so ribociclib may raise its levels and prolong opioid effects. This increases the risk of respiratory depression and excessive sedation.
How serious is the interaction between Ribociclib and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation and titrate sufentanil to the lowest effective dose; extend observation after dosing.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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