Drug interactions
Ribociclib + Ticagrelor
Severity: Moderate
Ribociclib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise ticagrelor exposure, increasing bleeding risk and dyspnea. Both drugs may have additional effects, including bradycardia and QT-related concerns with ribociclib.
What this interaction means in plain words
Ribociclib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated ticagrelor metabolism raises ticagrelor concentrations.
What to do
Monitor for bleeding and dyspnea and consider alternative P2Y12 inhibitors such as prasugrel if bleeding risk is high. Avoid if possible, and monitor ECG per ribociclib labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Ticagrelor?
MediHelp rates the interaction as moderate. Ribociclib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and may raise ticagrelor exposure, increasing bleeding risk and dyspnea. Both drugs may have additional effects, including bradycardia and QT-related concerns with ribociclib.
How serious is the interaction between Ribociclib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and dyspnea and consider alternative P2Y12 inhibitors such as prasugrel if bleeding risk is high. Avoid if possible, and monitor ECG per ribociclib labeling.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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