Drug interactions
Ribociclib + Tinidazole
Severity: Moderate
Ribociclib and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib prolongs the QT interval in a concentration-dependent manner, and tinidazole has been linked to QT prolongation in labeling. Together they may raise the risk of arrhythmia. Ribociclib can also inhibit CYP3A4, though its effect on tinidazole is likely small.
What this interaction means in plain words
Ribociclib and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition by ribociclib.
What to do
Monitor ECG and electrolytes if the combination is needed, and correct hypokalemia or hypomagnesemia. Consider an alternative antimicrobial in patients with existing QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Tinidazole?
MediHelp rates the interaction as moderate. Ribociclib and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib prolongs the QT interval in a concentration-dependent manner, and tinidazole has been linked to QT prolongation in labeling. Together they may raise the risk of arrhythmia. Ribociclib can also inhibit CYP3A4, though its effect on tinidazole is likely small.
How serious is the interaction between Ribociclib and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes if the combination is needed, and correct hypokalemia or hypomagnesemia. Consider an alternative antimicrobial in patients with existing QT prolongation.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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