Drug interactions
Ribociclib + Umeclidinium-vilanterol
Severity: Moderate
Ribociclib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and can raise vilanterol exposure, increasing beta-agonist adverse effects. Ribociclib also prolongs the QT interval in a dose-dependent way, so the combination may add to cardiac risk.
What this interaction means in plain words
Ribociclib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition by ribociclib increases vilanterol levels, with additive QT prolongation potential.
What to do
Monitor ECG and electrolytes (potassium, magnesium) during co-therapy. Watch for tachycardia, palpitations and tremor, and reassess if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Ribociclib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a CYP3A4 inhibitor and can raise vilanterol exposure, increasing beta-agonist adverse effects. Ribociclib also prolongs the QT interval in a dose-dependent way, so the combination may add to cardiac risk.
How serious is the interaction between Ribociclib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes (potassium, magnesium) during co-therapy. Watch for tachycardia, palpitations and tremor, and reassess if symptoms appear.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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