Drug interactions
Ribociclib + Vardenafil
Severity: Major
Ribociclib and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib causes dose-dependent QT prolongation and vardenafil has a modest QT effect. Combined use may add to the risk of torsades de pointes. Ribociclib is also a CYP3A4 inhibitor and may raise vardenafil exposure.
What this interaction means in plain words
Ribociclib and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition by ribociclib reducing vardenafil clearance.
What to do
Avoid the combination where possible and use another erectile dysfunction option. If unavoidable, monitor ECG and electrolytes and use a reduced vardenafil dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vardenafil?
MediHelp rates the interaction as major. Ribociclib and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib causes dose-dependent QT prolongation and vardenafil has a modest QT effect. Combined use may add to the risk of torsades de pointes. Ribociclib is also a CYP3A4 inhibitor and may raise vardenafil exposure.
How serious is the interaction between Ribociclib and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use another erectile dysfunction option. If unavoidable, monitor ECG and electrolytes and use a reduced vardenafil dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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