Drug interactions
Ribociclib + Venetoclax
Severity: Major
Ribociclib and Venetoclax: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a CYP3A4 inhibitor and may increase venetoclax exposure. Higher venetoclax levels increase the risk of neutropenia and tumor lysis syndrome.
What this interaction means in plain words
Ribociclib and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ribociclib belongs to Oncology; Venetoclax belongs to Miscellaneous.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of venetoclax, raising its concentrations.
What to do
Reduce the venetoclax dose in line with labeling for CYP3A inhibitors. Monitor blood counts and tumor lysis markers closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Ribociclib with Venetoclax?
MediHelp rates the interaction as major. Ribociclib and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib is a CYP3A4 inhibitor and may increase venetoclax exposure. Higher venetoclax levels increase the risk of neutropenia and tumor lysis syndrome.
How serious is the interaction between Ribociclib and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the venetoclax dose in line with labeling for CYP3A inhibitors. Monitor blood counts and tumor lysis markers closely.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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