Drug interactions
Ribociclib + Verapamil
Severity: Moderate
Ribociclib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise verapamil concentrations, increasing bradycardia, AV block and hypotension. Ribociclib also prolongs QT, adding to cardiac risk.
What this interaction means in plain words
Ribociclib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Ribociclib inhibits CYP3A4, reducing verapamil metabolism.
What to do
Monitor heart rate, blood pressure and ECG including QTc. Reduce the verapamil dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Verapamil?
MediHelp rates the interaction as moderate. Ribociclib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may raise verapamil concentrations, increasing bradycardia, AV block and hypotension. Ribociclib also prolongs QT, adding to cardiac risk.
How serious is the interaction between Ribociclib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG including QTc. Reduce the verapamil dose if bradycardia or hypotension develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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