Drug interactions
Ribociclib + Vinblastine
Severity: Moderate
Ribociclib and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise vinblastine concentrations. This can increase myelosuppression, neurotoxicity and constipation, and ribociclib itself causes neutropenia.
What this interaction means in plain words
Ribociclib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ribociclib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of vinblastine, with additive neutropenia.
What to do
Monitor blood counts and for neurotoxicity, and reduce the vinblastine dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ribociclib with Vinblastine?
MediHelp rates the interaction as moderate. Ribociclib and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise vinblastine concentrations. This can increase myelosuppression, neurotoxicity and constipation, and ribociclib itself causes neutropenia.
How serious is the interaction between Ribociclib and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for neurotoxicity, and reduce the vinblastine dose if toxicity develops.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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