Drug interactions
Ribociclib + Voxilaprevir
Severity: Minor
Ribociclib and Voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may raise voxilaprevir levels slightly because of CYP3A4 inhibition. Voxilaprevir is used with sofosbuvir and velpatasvir, and a clinically important effect is not expected.
What this interaction means in plain words
Ribociclib and Voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ribociclib belongs to Oncology; Voxilaprevir belongs to Anti Virals.
Why it happens
Ribociclib inhibits CYP3A4, a minor metabolic pathway for voxilaprevir.
What to do
No dose adjustment is required; monitor for gastrointestinal and hepatic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Voxilaprevir
- Apalutamide + Voxilaprevir Contraindicated
- Phenytoin + Voxilaprevir Contraindicated
- Bosentan + Voxilaprevir Major
- Carbamazepine + Voxilaprevir Major
- Efavirenz + Voxilaprevir Major
- Enzalutamide + Voxilaprevir Major
Frequently asked questions
Can I take Ribociclib with Voxilaprevir?
MediHelp rates the interaction as minor. Ribociclib and Voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib may raise voxilaprevir levels slightly because of CYP3A4 inhibition. Voxilaprevir is used with sofosbuvir and velpatasvir, and a clinically important effect is not expected.
How serious is the interaction between Ribociclib and Voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for gastrointestinal and hepatic adverse effects.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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