Drug interactions
Rifabutin + Trimipramine
Severity: Moderate
Rifabutin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an inducer of hepatic enzymes and may lower trimipramine concentrations, potentially reducing antidepressant effect. The induction is weaker than with rifampicin.
What this interaction means in plain words
Rifabutin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Trimipramine belongs to Central Nervous System.
Why it happens
Induction of CYP-mediated metabolism of trimipramine by rifabutin.
What to do
Monitor clinical antidepressant response and consider a higher trimipramine dose or plasma level guidance. Reassess the dose when rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Trimipramine?
MediHelp rates the interaction as moderate. Rifabutin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is an inducer of hepatic enzymes and may lower trimipramine concentrations, potentially reducing antidepressant effect. The induction is weaker than with rifampicin.
How serious is the interaction between Rifabutin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical antidepressant response and consider a higher trimipramine dose or plasma level guidance. Reassess the dose when rifabutin is stopped.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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