Drug interactions
Rifabutin + Vortioxetine
Severity: Moderate
Rifabutin and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces hepatic enzymes and may lower vortioxetine concentrations, risking loss of antidepressant effect. Labeling for vortioxetine advises considering a dose increase with broad enzyme inducers given long term.
What this interaction means in plain words
Rifabutin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifabutin belongs to Anti Bacterial; Vortioxetine belongs to Central Nervous System.
Why it happens
Rifabutin induces CYP enzymes including CYP3A4, increasing vortioxetine clearance.
What to do
Monitor clinical response and consider increasing the vortioxetine dose up to the labeled maximum if prolonged co-therapy is needed. Return to the original dose within about two weeks after stopping rifabutin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Rifabutin with Vortioxetine?
MediHelp rates the interaction as moderate. Rifabutin and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces hepatic enzymes and may lower vortioxetine concentrations, risking loss of antidepressant effect. Labeling for vortioxetine advises considering a dose increase with broad enzyme inducers given long term.
How serious is the interaction between Rifabutin and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider increasing the vortioxetine dose up to the labeled maximum if prolonged co-therapy is needed. Return to the original dose within about two weeks after stopping rifabutin.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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