Drug interactions
Rifampicin + Tipranavir
Severity: Contraindicated
Rifampicin and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin strongly induces CYP3A4 and greatly lowers tipranavir/ritonavir concentrations. This risks loss of HIV virologic control and resistance.
What this interaction means in plain words
Rifampicin and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rifampicin belongs to Anti Bacterial; Tipranavir belongs to Anti Virals.
Why it happens
Rifampicin induces CYP3A4 and P-gp, accelerating tipranavir clearance.
What to do
Do not co-administer; use a rifabutin-based or alternative antimycobacterial regimen with specialist advice.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Tipranavir?
MediHelp rates the interaction as contraindicated. Rifampicin and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin strongly induces CYP3A4 and greatly lowers tipranavir/ritonavir concentrations. This risks loss of HIV virologic control and resistance.
How serious is the interaction between Rifampicin and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a rifabutin-based or alternative antimycobacterial regimen with specialist advice.
What other medicines interact with Tipranavir?
MediHelp also lists interactions of Tipranavir with, for example, Alfuzosin, Amiodarone, Atorvastatin. The full list is on the Tipranavir page.
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