Drug interactions
Rifampin + Riluzole
Severity: Moderate
Rifampin and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a strong enzyme inducer and may increase riluzole metabolism, lowering its exposure. Reduced efficacy is possible during treatment.
What this interaction means in plain words
Rifampin and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP1A2 and increases riluzole clearance.
What to do
Monitor clinical response to riluzole during and after rifampin therapy. Adjust the riluzole dose if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Frequently asked questions
Can I take Rifampin with Riluzole?
MediHelp rates the interaction as moderate. Rifampin and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a strong enzyme inducer and may increase riluzole metabolism, lowering its exposure. Reduced efficacy is possible during treatment.
How serious is the interaction between Rifampin and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to riluzole during and after rifampin therapy. Adjust the riluzole dose if response is lost.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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