Drug interactions
Rifampin + Vilazodone
Severity: Moderate
Rifampin and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent CYP3A4 inducer and can substantially reduce vilazodone exposure. This may result in loss of antidepressant effect.
What this interaction means in plain words
Rifampin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces intestinal and hepatic CYP3A4, increasing the metabolism of vilazodone.
What to do
Monitor for loss of antidepressant response and consider increasing the vilazodone dose as needed, not exceeding the labeled maximum. Return to the usual dose within about 1-2 weeks of stopping rifampin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Rifampin with Vilazodone?
MediHelp rates the interaction as moderate. Rifampin and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent CYP3A4 inducer and can substantially reduce vilazodone exposure. This may result in loss of antidepressant effect.
How serious is the interaction between Rifampin and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and consider increasing the vilazodone dose as needed, not exceeding the labeled maximum. Return to the usual dose within about 1-2 weeks of stopping rifampin.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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