Drug interactions
Rifaximin + Tepotinib
Severity: Moderate
Rifaximin and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Rifaximin is a P-gp substrate with low baseline systemic absorption, so levels may increase. The clinical consequence is probably modest in patients with normal liver function.
What this interaction means in plain words
Rifaximin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifaximin belongs to Anti Bacterial; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits P-glycoprotein efflux, raising systemic rifaximin exposure.
What to do
Monitor for rifaximin adverse effects, especially in severe hepatic impairment. Reassess the need for rifaximin if the combination is long-term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Rifaximin with Tepotinib?
MediHelp rates the interaction as moderate. Rifaximin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may increase exposure to P-gp substrates. Rifaximin is a P-gp substrate with low baseline systemic absorption, so levels may increase. The clinical consequence is probably modest in patients with normal liver function.
How serious is the interaction between Rifaximin and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects, especially in severe hepatic impairment. Reassess the need for rifaximin if the combination is long-term.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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