Drug interactions
Rifaximin + Tucatinib
Severity: Moderate
Rifaximin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-glycoprotein and may increase systemic rifaximin exposure. Since rifaximin absorption is normally low, the effect is generally modest but can matter in hepatic impairment.
What this interaction means in plain words
Rifaximin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rifaximin belongs to Anti Bacterial; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein, reducing efflux of rifaximin.
What to do
Monitor for rifaximin adverse effects, especially in patients with liver impairment. No routine dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Rifaximin with Tucatinib?
MediHelp rates the interaction as moderate. Rifaximin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits P-glycoprotein and may increase systemic rifaximin exposure. Since rifaximin absorption is normally low, the effect is generally modest but can matter in hepatic impairment.
How serious is the interaction between Rifaximin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rifaximin adverse effects, especially in patients with liver impairment. No routine dose change is needed.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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