Drug interactions
Rilonacept + Ustekinumab
Severity: Major
Rilonacept and Ustekinumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilonacept blocks IL-1 and ustekinumab blocks IL-12/23, so the two biologics together may impair host defence. Serious infections are the main concern.
What this interaction means in plain words
Rilonacept and Ustekinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rilonacept belongs to Miscellaneous; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from simultaneous cytokine pathway inhibition.
What to do
Avoid combining the two biologics unless clearly necessary. If used together, monitor closely for infection and hold therapy if a serious infection develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Rilonacept
Frequently asked questions
Can I take Rilonacept with Ustekinumab?
MediHelp rates the interaction as major. Rilonacept and Ustekinumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rilonacept blocks IL-1 and ustekinumab blocks IL-12/23, so the two biologics together may impair host defence. Serious infections are the main concern.
How serious is the interaction between Rilonacept and Ustekinumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two biologics unless clearly necessary. If used together, monitor closely for infection and hold therapy if a serious infection develops.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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