Drug interactions
Rimegepant + Ritonavir
Severity: Major
Rimegepant and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits both CYP3A4 and P-glycoprotein, which can raise rimegepant exposure. Higher levels may increase adverse effects such as nausea and hypersensitivity reactions.
What this interaction means in plain words
Rimegepant and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rimegepant belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4 metabolism and P-gp efflux of rimegepant.
What to do
Avoid taking rimegepant with strong CYP3A4 inhibitors such as ritonavir, and use an alternative acute migraine treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Rimegepant with Ritonavir?
MediHelp rates the interaction as major. Rimegepant and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir inhibits both CYP3A4 and P-glycoprotein, which can raise rimegepant exposure. Higher levels may increase adverse effects such as nausea and hypersensitivity reactions.
How serious is the interaction between Rimegepant and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid taking rimegepant with strong CYP3A4 inhibitors such as ritonavir, and use an alternative acute migraine treatment.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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