Drug interactions
Rimegepant + Secobarbital
Severity: Moderate
Rimegepant and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce rimegepant levels and its efficacy for migraine.
What this interaction means in plain words
Rimegepant and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP3A4 increases rimegepant metabolism.
What to do
Avoid repeat rimegepant dosing within 48 hours with inducers per labeling and monitor migraine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Secobarbital?
MediHelp rates the interaction as moderate. Rimegepant and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may reduce rimegepant levels and its efficacy for migraine.
How serious is the interaction between Rimegepant and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid repeat rimegepant dosing within 48 hours with inducers per labeling and monitor migraine response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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