Drug interactions
Rimegepant + Sertraline
Severity: Minor
Rimegepant and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rimegepant is a CYP3A4 substrate and exposure rises with moderate or strong CYP3A4 inhibitors. Sertraline is only a weak CYP3A4 inhibitor, so any effect is expected to be small.
What this interaction means in plain words
Rimegepant and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rimegepant belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline slightly reducing rimegepant clearance.
What to do
No dose adjustment is needed; use rimegepant at the standard dose and no more than once in 24 hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Sertraline?
MediHelp rates the interaction as minor. Rimegepant and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rimegepant is a CYP3A4 substrate and exposure rises with moderate or strong CYP3A4 inhibitors. Sertraline is only a weak CYP3A4 inhibitor, so any effect is expected to be small.
How serious is the interaction between Rimegepant and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; use rimegepant at the standard dose and no more than once in 24 hours.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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