Drug interactions
Rimegepant + Ticagrelor
Severity: Moderate
Rimegepant and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor inhibits P-glycoprotein and may raise rimegepant exposure. Rimegepant is generally well tolerated, so the increase is of limited clinical concern.
What this interaction means in plain words
Rimegepant and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Ticagrelor belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and other P-gp efflux increases rimegepant absorption and exposure.
What to do
Avoid a second rimegepant dose within 48 hours when taken with a P-gp inhibitor, per labeling. Monitor for adverse effects such as nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Ticagrelor?
MediHelp rates the interaction as moderate. Rimegepant and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor inhibits P-glycoprotein and may raise rimegepant exposure. Rimegepant is generally well tolerated, so the increase is of limited clinical concern.
How serious is the interaction between Rimegepant and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with a P-gp inhibitor, per labeling. Monitor for adverse effects such as nausea.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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