Drug interactions
Rimegepant + Verapamil
Severity: Moderate
Rimegepant and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-gp and may increase rimegepant exposure, with potential for more adverse effects such as nausea and hypersensitivity. The increase is expected to be modest.
What this interaction means in plain words
Rimegepant and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of P-gp efflux of rimegepant, increasing its absorption.
What to do
Avoid a second rimegepant dose within 48 hours when taken with P-gp inhibitors, per labeling. Monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Rimegepant
Frequently asked questions
Can I take Rimegepant with Verapamil?
MediHelp rates the interaction as moderate. Rimegepant and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-gp and may increase rimegepant exposure, with potential for more adverse effects such as nausea and hypersensitivity. The increase is expected to be modest.
How serious is the interaction between Rimegepant and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with P-gp inhibitors, per labeling. Monitor for adverse effects.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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