Drug interactions
Rimegepant + Voxelotor
Severity: Moderate
Rimegepant and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 in vitro and may modestly increase exposure to sensitive substrates such as rimegepant. The clinical significance is uncertain.
What this interaction means in plain words
Rimegepant and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rimegepant belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by voxelotor.
What to do
For acute migraine, avoid a second rimegepant dose within 48 hours. No adjustment is needed for preventive use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Rimegepant with Voxelotor?
MediHelp rates the interaction as moderate. Rimegepant and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 in vitro and may modestly increase exposure to sensitive substrates such as rimegepant. The clinical significance is uncertain.
How serious is the interaction between Rimegepant and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For acute migraine, avoid a second rimegepant dose within 48 hours. No adjustment is needed for preventive use.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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