Drug interactions
Risperidone + Salmeterol
Severity: Moderate
Risperidone and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone has a modest QT-prolonging effect and salmeterol can cause tachycardia and hypokalemia. The combination may slightly increase proarrhythmic risk in susceptible patients.
What this interaction means in plain words
Risperidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia as a contributing factor.
What to do
Check ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Salmeterol?
MediHelp rates the interaction as moderate. Risperidone and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone has a modest QT-prolonging effect and salmeterol can cause tachycardia and hypokalemia. The combination may slightly increase proarrhythmic risk in susceptible patients.
How serious is the interaction between Risperidone and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with cardiac risk factors or other QT-prolonging drugs. Correct potassium and magnesium deficits.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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