Drug interactions
Risperidone + Selegiline
Severity: Moderate
Risperidone and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is a MAO-B inhibitor that can inhibit MAO-A at higher doses and has serotonergic activity, so combined use with risperidone carries a theoretical serotonin syndrome risk. Risperidone's dopamine blockade also opposes selegiline's effect in Parkinson's disease and may worsen motor symptoms.
What this interaction means in plain words
Risperidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine receptors plus possible additive serotonergic effects.
What to do
Avoid risperidone in Parkinson's disease where possible, preferring quetiapine or clozapine. Monitor motor function and for serotonin toxicity signs if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Risperidone with Selegiline?
MediHelp rates the interaction as moderate. Risperidone and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline is a MAO-B inhibitor that can inhibit MAO-A at higher doses and has serotonergic activity, so combined use with risperidone carries a theoretical serotonin syndrome risk. Risperidone's dopamine blockade also opposes selegiline's effect in Parkinson's disease and may worsen motor symptoms.
How serious is the interaction between Risperidone and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid risperidone in Parkinson's disease where possible, preferring quetiapine or clozapine. Monitor motor function and for serotonin toxicity signs if combined.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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