Drug interactions
Risperidone + Selpercatinib
Severity: Major
Risperidone and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and risperidone also has QT-prolonging potential. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Risperidone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Risperidone belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes regularly. Consider an alternative antipsychotic with lower QT risk if the QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Selpercatinib
Frequently asked questions
Can I take Risperidone with Selpercatinib?
MediHelp rates the interaction as major. Risperidone and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selpercatinib can prolong the QT interval, and risperidone also has QT-prolonging potential. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Risperidone and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes regularly. Consider an alternative antipsychotic with lower QT risk if the QTc rises significantly.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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