Drug interactions
Risperidone + Sotorasib
Severity: Moderate
Risperidone and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib may induce or modulate P-glycoprotein, which can alter the transport of risperidone and its active metabolite 9-hydroxyrisperidone. This may reduce antipsychotic exposure and efficacy, although the magnitude is uncertain.
What this interaction means in plain words
Risperidone and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Sotorasib belongs to Oncology.
Why it happens
Modulation of P-glycoprotein–mediated efflux of risperidone by sotorasib.
What to do
Monitor for loss of psychiatric symptom control or new adverse effects and adjust the risperidone dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Risperidone with Sotorasib?
MediHelp rates the interaction as moderate. Risperidone and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib may induce or modulate P-glycoprotein, which can alter the transport of risperidone and its active metabolite 9-hydroxyrisperidone. This may reduce antipsychotic exposure and efficacy, although the magnitude is uncertain.
How serious is the interaction between Risperidone and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of psychiatric symptom control or new adverse effects and adjust the risperidone dose according to clinical response.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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