Drug interactions
Risperidone + Tolterodine
Severity: Moderate
Risperidone and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone is a CYP2D6 substrate with weak anticholinergic activity and mild QT effect. Combined with tolterodine, anticholinergic effects and QT risk may modestly increase.
What this interaction means in plain words
Risperidone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Risperidone belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic and QT-prolonging effects, with possible competition at CYP2D6.
What to do
Monitor for anticholinergic effects and obtain an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Risperidone with Tolterodine?
MediHelp rates the interaction as moderate. Risperidone and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone is a CYP2D6 substrate with weak anticholinergic activity and mild QT effect. Combined with tolterodine, anticholinergic effects and QT risk may modestly increase.
How serious is the interaction between Risperidone and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and obtain an ECG if other QT risk factors exist.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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