Drug interactions
Risperidone + Tolvaptan
Severity: Minor
Risperidone and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and could increase risperidone concentrations. The effect is probably small, but may increase sedation, hypotension or extrapyramidal effects.
What this interaction means in plain words
Risperidone and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Risperidone belongs to Central Nervous System; Tolvaptan belongs to Endocrine.
Why it happens
Tolvaptan inhibits P-glycoprotein efflux, possibly increasing risperidone exposure.
What to do
No routine adjustment is required; monitor for sedation, orthostatic hypotension and extrapyramidal symptoms. Lower the risperidone dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Risperidone with Tolvaptan?
MediHelp rates the interaction as minor. Risperidone and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein and could increase risperidone concentrations. The effect is probably small, but may increase sedation, hypotension or extrapyramidal effects.
How serious is the interaction between Risperidone and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor for sedation, orthostatic hypotension and extrapyramidal symptoms. Lower the risperidone dose if adverse effects emerge.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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