Drug interactions
Ritlecitinib + Thioridazine
Severity: Moderate
Ritlecitinib and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib may inhibit CYP3A4 and raise exposure to sensitive substrates. Thioridazine is mainly cleared by CYP2D6, so the effect is likely modest, but it has a narrow safety margin because of QT prolongation.
What this interaction means in plain words
Ritlecitinib and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritlecitinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Possible CYP3A4 inhibition by ritlecitinib reducing a minor thioridazine clearance pathway.
What to do
Monitor ECG and QTc if combined, and watch for sedation or arrhythmia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ritlecitinib and Thioridazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ritlecitinib with Thioridazine?
MediHelp rates the interaction as moderate. Ritlecitinib and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib may inhibit CYP3A4 and raise exposure to sensitive substrates. Thioridazine is mainly cleared by CYP2D6, so the effect is likely modest, but it has a narrow safety margin because of QT prolongation.
How serious is the interaction between Ritlecitinib and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc if combined, and watch for sedation or arrhythmia symptoms.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
