Drug interactions
Ritlecitinib + Warfarin
Severity: Minor
Ritlecitinib and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib may inhibit CYP3A4, which has a minor role in clearing the R-enantiomer of warfarin. Clinically meaningful change in INR is uncertain and probably small.
What this interaction means in plain words
Ritlecitinib and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ritlecitinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 by ritlecitinib slightly reducing R-warfarin clearance.
What to do
Check INR after starting or stopping ritlecitinib, as for any new drug in a warfarin patient. Adjust the warfarin dose only if INR shifts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Ritlecitinib with Warfarin?
MediHelp rates the interaction as minor. Ritlecitinib and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritlecitinib may inhibit CYP3A4, which has a minor role in clearing the R-enantiomer of warfarin. Clinically meaningful change in INR is uncertain and probably small.
How serious is the interaction between Ritlecitinib and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or stopping ritlecitinib, as for any new drug in a warfarin patient. Adjust the warfarin dose only if INR shifts.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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