Drug interactions
Ritonavir + Rosiglitazone
Severity: Moderate
Ritonavir and Rosiglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-containing regimens can cause insulin resistance and hyperglycemia, which may work against the glucose-lowering effect of rosiglitazone. Glycemic control may deteriorate in patients with diabetes who start or continue ritonavir.
What this interaction means in plain words
Ritonavir and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Rosiglitazone belongs to Endocrine.
Why it happens
Protease inhibitors induce insulin resistance and impair glucose metabolism, opposing the insulin-sensitizing action of rosiglitazone (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c after starting or stopping ritonavir. Adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Rosiglitazone?
MediHelp rates the interaction as moderate. Ritonavir and Rosiglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-containing regimens can cause insulin resistance and hyperglycemia, which may work against the glucose-lowering effect of rosiglitazone. Glycemic control may deteriorate in patients with diabetes who start or continue ritonavir.
How serious is the interaction between Ritonavir and Rosiglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping ritonavir. Adjust the antidiabetic regimen as needed.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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