Drug interactions
Ritonavir + Rosuvastatin
Severity: Moderate
Ritonavir and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir raises rosuvastatin exposure moderately, increasing the risk of myopathy.
What this interaction means in plain words
Ritonavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ritonavir belongs to Anti Virals; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1 reduces hepatic uptake of rosuvastatin.
What to do
Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Ritonavir with Rosuvastatin?
MediHelp rates the interaction as moderate. Ritonavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir raises rosuvastatin exposure moderately, increasing the risk of myopathy.
How serious is the interaction between Ritonavir and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and monitor for muscle symptoms. Check CK if symptoms occur.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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