Drug interactions
Roflumilast + Tipranavir
Severity: Moderate
Roflumilast and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir is a strong net CYP3A4 inhibitor, though tipranavir itself has mixed inhibitory and inducing effects. Roflumilast exposure may rise, with more PDE4-related adverse effects.
What this interaction means in plain words
Roflumilast and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Roflumilast belongs to Respiratory; Tipranavir belongs to Anti Virals.
Why it happens
Tipranavir/ritonavir inhibits CYP3A4, reducing roflumilast metabolism.
What to do
Monitor for diarrhea, weight loss, insomnia and mood changes. Stop roflumilast if they become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Roflumilast with Tipranavir?
MediHelp rates the interaction as moderate. Roflumilast and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir is a strong net CYP3A4 inhibitor, though tipranavir itself has mixed inhibitory and inducing effects. Roflumilast exposure may rise, with more PDE4-related adverse effects.
How serious is the interaction between Roflumilast and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, weight loss, insomnia and mood changes. Stop roflumilast if they become troublesome.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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